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Klatskin tumor

MedGen UID:
61664
Concept ID:
C0206702
Neoplastic Process
Synonyms: Hilar Cholangiocarcinoma; Klatskin's tumor
SNOMED CT: Klatskin's tumor (6492006); Klatskin's tumor morphology (6492006); Klatskin tumor (253017000); Klatskin tumor (6492006); Klatskin's tumor (253017000); Hilar cholangiocarcinoma (253017000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0003345
Orphanet: ORPHA99978

Definition

Klatskin tumor is an extra-hepatic cholangiocarcinoma (CCA, see this term) arising in the junction of the main right or left hepatic ducts to form the common hepatic duct. [from ORDO]

Professional guidelines

PubMed

Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, Cristoferi L, Ciaccio A, Cortinovis DL, Invernizzi P, Massironi S
Ann Hepatol 2022 Sep-Oct;27(5):100737. Epub 2022 Jul 7 doi: 10.1016/j.aohep.2022.100737. PMID: 35809836
Kawashima H, Ohno E, Ishikawa T, Mizutani Y, Iida T, Yamamura T, Kakushima N, Furukawa K, Nakamura M
Dig Endosc 2022 Sep;34(6):1147-1156. Epub 2022 Jun 2 doi: 10.1111/den.14317. PMID: 35377509
Dondossola D, Ghidini M, Grossi F, Rossi G, Foschi D
World J Gastroenterol 2020 Jul 7;26(25):3542-3561. doi: 10.3748/wjg.v26.i25.3542. PMID: 32742125Free PMC Article

Recent clinical studies

Etiology

Dar FS, Abbas Z, Ahmed I, Atique M, Aujla UI, Azeemuddin M, Aziz Z, Bhatti ABH, Bangash TA, Butt AS, Butt OT, Dogar AW, Farooqi JI, Hanif F, Haider J, Haider S, Hassan SM, Jabbar AA, Khan AN, Khan MS, Khan MY, Latif A, Luck NH, Malik AK, Rashid K, Rashid S, Salih M, Saeed A, Salamat A, Tayyab GU, Yusuf A, Zia HH, Naveed A
World J Gastroenterol 2024 Mar 7;30(9):1018-1042. doi: 10.3748/wjg.v30.i9.1018. PMID: 38577184Free PMC Article
Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, Cristoferi L, Ciaccio A, Cortinovis DL, Invernizzi P, Massironi S
Ann Hepatol 2022 Sep-Oct;27(5):100737. Epub 2022 Jul 7 doi: 10.1016/j.aohep.2022.100737. PMID: 35809836
Mueller M, Breuer E, Mizuno T, Bartsch F, Ratti F, Benzing C, Ammar-Khodja N, Sugiura T, Takayashiki T, Hessheimer A, Kim HS, Ruzzenente A, Ahn KS, Wong T, Bednarsch J, D'Silva M, Koerkamp BG, Jeddou H, López-López V, de Ponthaud C, Yonkus JA, Ismail W, Nooijen LE, Hidalgo-Salinas C, Kontis E, Wagner KC, Gunasekaran G, Higuchi R, Gleisner A, Shwaartz C, Sapisochin G, Schulick RD, Yamamoto M, Noji T, Hirano S, Schwartz M, Oldhafer KJ, Prachalias A, Fusai GK, Erdmann JI, Line PD, Smoot RL, Soubrane O, Robles-Campos R, Boudjema K, Polak WG, Han HS, Neumann UP, Lo CM, Kang KJ, Guglielmi A, Park JS, Fondevila C, Ohtsuka M, Uesaka K, Adam R, Pratschke J, Aldrighetti L, De Oliveira ML, Gores GJ, Lang H, Nagino M, Clavien PA
Ann Surg 2021 Nov 1;274(5):780-788. doi: 10.1097/SLA.0000000000005103. PMID: 34334638
Soares KC, Jarnagin WR
Ann Surg Oncol 2021 Aug;28(8):4158-4170. Epub 2021 Apr 7 doi: 10.1245/s10434-021-09871-6. PMID: 33829358Free PMC Article
Blechacz B
Gut Liver 2017 Jan 15;11(1):13-26. doi: 10.5009/gnl15568. PMID: 27928095Free PMC Article

Diagnosis

Harrison JM, Visser BC
Surg Clin North Am 2024 Dec;104(6):1281-1293. Epub 2024 May 10 doi: 10.1016/j.suc.2024.04.003. PMID: 39448128
Mao S, Shan Y, Yu X, Yang Y, Wu S, Lu C
BMC Cancer 2024 Mar 4;24(1):297. doi: 10.1186/s12885-024-12068-1. PMID: 38438912Free PMC Article
Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, Cristoferi L, Ciaccio A, Cortinovis DL, Invernizzi P, Massironi S
Ann Hepatol 2022 Sep-Oct;27(5):100737. Epub 2022 Jul 7 doi: 10.1016/j.aohep.2022.100737. PMID: 35809836
Khan AS, Dageforde LA
Surg Clin North Am 2019 Apr;99(2):315-335. Epub 2019 Feb 10 doi: 10.1016/j.suc.2018.12.004. PMID: 30846037
Cillo U, Fondevila C, Donadon M, Gringeri E, Mocchegiani F, Schlitt HJ, Ijzermans JNM, Vivarelli M, Zieniewicz K, Olde Damink SWM, Groot Koerkamp B
Liver Int 2019 May;39 Suppl 1(Suppl Suppl 1):143-155. doi: 10.1111/liv.14089. PMID: 30843343Free PMC Article

Therapy

Patrono D, De Stefano N, Romagnoli R
Curr Opin Organ Transplant 2024 Aug 1;29(4):255-265. Epub 2024 May 8 doi: 10.1097/MOT.0000000000001149. PMID: 38716718
Nooijen LE, Franssen S, Buis CI, Dejong CHC, den Dulk M, van Delden OM, Ijzermans JN, Groot Koerkamp B, Kazemier G, van Lienden K, Klümpen HJ, Kuipers H, Olij B, Porte RJ, Rauws EA, Voermans RP, van Gulik TM, Erdmann JI, Roos E, Coelen RJ
HPB (Oxford) 2023 Feb;25(2):210-217. Epub 2022 Oct 21 doi: 10.1016/j.hpb.2022.10.009. PMID: 36376222
Soares KC, Jarnagin WR
Ann Surg Oncol 2021 Aug;28(8):4158-4170. Epub 2021 Apr 7 doi: 10.1245/s10434-021-09871-6. PMID: 33829358Free PMC Article
Cillo U, Fondevila C, Donadon M, Gringeri E, Mocchegiani F, Schlitt HJ, Ijzermans JNM, Vivarelli M, Zieniewicz K, Olde Damink SWM, Groot Koerkamp B
Liver Int 2019 May;39 Suppl 1(Suppl Suppl 1):143-155. doi: 10.1111/liv.14089. PMID: 30843343Free PMC Article
Bhardwaj N, Garcea G, Dennison AR, Maddern GJ
World J Surg 2015 Nov;39(11):2748-56. doi: 10.1007/s00268-015-3125-2. PMID: 26133907

Prognosis

Mao S, Shan Y, Yu X, Yang Y, Wu S, Lu C
BMC Cancer 2024 Mar 4;24(1):297. doi: 10.1186/s12885-024-12068-1. PMID: 38438912Free PMC Article
Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, Cristoferi L, Ciaccio A, Cortinovis DL, Invernizzi P, Massironi S
Ann Hepatol 2022 Sep-Oct;27(5):100737. Epub 2022 Jul 7 doi: 10.1016/j.aohep.2022.100737. PMID: 35809836
Mueller M, Breuer E, Mizuno T, Bartsch F, Ratti F, Benzing C, Ammar-Khodja N, Sugiura T, Takayashiki T, Hessheimer A, Kim HS, Ruzzenente A, Ahn KS, Wong T, Bednarsch J, D'Silva M, Koerkamp BG, Jeddou H, López-López V, de Ponthaud C, Yonkus JA, Ismail W, Nooijen LE, Hidalgo-Salinas C, Kontis E, Wagner KC, Gunasekaran G, Higuchi R, Gleisner A, Shwaartz C, Sapisochin G, Schulick RD, Yamamoto M, Noji T, Hirano S, Schwartz M, Oldhafer KJ, Prachalias A, Fusai GK, Erdmann JI, Line PD, Smoot RL, Soubrane O, Robles-Campos R, Boudjema K, Polak WG, Han HS, Neumann UP, Lo CM, Kang KJ, Guglielmi A, Park JS, Fondevila C, Ohtsuka M, Uesaka K, Adam R, Pratschke J, Aldrighetti L, De Oliveira ML, Gores GJ, Lang H, Nagino M, Clavien PA
Ann Surg 2021 Nov 1;274(5):780-788. doi: 10.1097/SLA.0000000000005103. PMID: 34334638
Anderson B, Doyle MBM
Surg Oncol Clin N Am 2019 Oct;28(4):601-617. Epub 2019 Aug 2 doi: 10.1016/j.soc.2019.06.003. PMID: 31472908
Friman S
Scand J Surg 2011;100(1):30-4. doi: 10.1177/145749691110000106. PMID: 21491796

Clinical prediction guides

Mao S, Shan Y, Yu X, Yang Y, Wu S, Lu C
BMC Cancer 2024 Mar 4;24(1):297. doi: 10.1186/s12885-024-12068-1. PMID: 38438912Free PMC Article
Ratti F, Marino R, Olthof PB, Pratschke J, Erdmann JI, Neumann UP, Prasad R, Jarnagin WR, Schnitzbauer AA, Cescon M, Guglielmi A, Lang H, Nadalin S, Topal B, Maithel SK, Hoogwater FJH, Alikhanov R, Troisi R, Sparrelid E, Roberts KJ, Malagò M, Hagendoorn J, Malik HZ, Olde Damink SWM, Kazemier G, Schadde E, Charco R, de Reuver PR, Groot Koerkamp B, Aldrighetti L; Perihilar Cholangiocarcinoma Collaboration Group
Hepatology 2024 Feb 1;79(2):341-354. Epub 2023 Aug 3 doi: 10.1097/HEP.0000000000000554. PMID: 37530544
Nechita VI, Moiş E, Furcea L, Nechita MA, Graur F
Medicina (Kaunas) 2022 Dec 5;58(12) doi: 10.3390/medicina58121788. PMID: 36556990Free PMC Article
Ilyas SI, Eaton J, Yang JD, Chandrasekhara V, Gores GJ
Semin Liver Dis 2018 May;38(2):160-169. Epub 2018 Jun 5 doi: 10.1055/s-0038-1655775. PMID: 29871021Free PMC Article
Kimbrough CW, Cloyd JM, Pawlik TM
Expert Rev Anticancer Ther 2018 Jul;18(7):673-683. Epub 2018 May 11 doi: 10.1080/14737140.2018.1473039. PMID: 29726723

Recent systematic reviews

Xu B, Zhao W, Chang J, Yin J, Wang N, Dong Z, Zhi X, Li T, Chen Z
World J Surg Oncol 2023 May 18;21(1):153. doi: 10.1186/s12957-023-03037-2. PMID: 37202795Free PMC Article
Cipriani F, Ratti F, Fiorentini G, Reineke R, Aldrighetti L
Updates Surg 2021 Apr;73(2):359-377. Epub 2021 Feb 22 doi: 10.1007/s13304-021-01006-6. PMID: 33615423
Tang Z, Yang Y, Meng W, Li X
Medicine (Baltimore) 2017 Oct;96(43):e8372. doi: 10.1097/MD.0000000000008372. PMID: 29069029Free PMC Article
Celotti A, Solaini L, Montori G, Coccolini F, Tognali D, Baiocchi G
Eur J Surg Oncol 2017 Sep;43(9):1628-1635. Epub 2017 Apr 18 doi: 10.1016/j.ejso.2017.04.001. PMID: 28477976
Lau SH, Lau WY
Hepatobiliary Pancreat Dis Int 2012 Feb;11(1):12-7. doi: 10.1016/s1499-3872(11)60119-7. PMID: 22251465

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